Type 2 Diabetes Mellitus
Progressive insulin resistance coupled with pancreatic beta-cell secretory defect
Educational content only — not medical advice.
Anatomy
Polyuria, polydipsia, persistent fatigue, polyphagia, blurred vision, slow healing of wounds.
Action
Peripheral tissues resist insulin signaling, prompting beta-cell hypersecretion until progressive exhaustion yields chronic hyperglycemia and vascular microangiopathy.
Clinical notes
Strict glycemic and blood pressure control mitigates retinopathy, nephropathy, and diabetic neuropathy. Therapeutics span metformin, SGLT2i, and GLP-1 agonists.