Parkinson’s Disease (Paralysis Agitans)
Progressive neurodegenerative disorder driven by substantia nigra dopaminergic depletion
Educational content only — not medical advice.
Anatomy
Resting "pill-rolling" tremor, cogwheel muscular rigidity, bradykinesia, festinating gait, postural instability.
Action
Misfolded alpha-synuclein aggregates into intracellular Lewy bodies, accelerating degeneration of pars compacta dopaminergic projections to striatum.
Clinical notes
Clinical diagnosis. Levodopa-carbidopa is the pharmacologic gold standard; advanced refractory tremor responds to Deep Brain Stimulation (DBS).